Research Overview
Our research focuses on understanding the complex interplay between the microbiome, the immune system, and the pathophysiology of critical illness, particularly in the context of sepsis and intensive care. We investigate the microbiological and immunological mechanisms underlying infections and organ dysfunction in ICU patients, with a particular emphasis on gut microbiota dysbiosis and its contribution to nosocomial infections and systemic inflammation.
Through multi-dimensional profiling approaches, we aim to characterize microbiota-immune interactions at both the cellular and molecular levels. This includes in-depth studies of host-microbe dynamics and immune dysfunction during critical illness, leveraging advanced techniques such as intravital imaging and the use of germ-free and gnotobiotic animal models to dissect the mechanisms driving dysbiosis and immune regulation.
A key objective of our program is the translation of these findings into novel therapeutic strategies. We are developing precision microbiota-editing tools to restore healthy microbiota-immune mutualism and exploring innovative immunotherapies to enhance host defense mechanisms against infections and sepsis. Our ultimate goal is to enable targeted, mechanism-based interventions to prevent and treat infections in critically ill patients.
Acknowledgement
